CAS No. 1449228-40-3
Batch:
Purity:96.69
Chemical Structure
Check the
Senexin B
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 4-[2-[6-(4-methylpiperazine-1-carbonyl)naphthalen-2-yl]ethylamino]quinazoline-6-carbonitrile | |
|---|---|---|
| CAS Number | 1449228-40-3 | |
| Molecular Formula |
C27H26N6O |
|
| Molecular Weight (MW) | 450.54 | |
| InChIKey | VNADJTWHOAMTLY-UHFFFAOYSA-N |
Biological Activity
Senexin B is a potent and selective small-molecule inhibitor targeting CDK8 and CDK19 Mediator kinases. By blocking the Mediator kinase module, it suppresses estrogen-induced transcription, reduces phosphorylated RNA polymerase II recruitment, and inhibits cancer cell proliferation. Furthermore, targeted inhibition of CDK8 and CDK19 modulates downstream signaling through the PI3K/AKT/mTOR pathway, suppressing xenograft tumor growth in vivo. [1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
11 mg/mL
(24.41 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.