CAS No. 204005-46-9
| IUPAC Name | 3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1H-indol-2-one | |
|---|---|---|
| CAS Number | 204005-46-9 | |
| Molecular Formula |
C15H14N2O |
|
| Molecular Weight (MW) | 238.28 | |
| SMILES | CC1=CC(=C(N1)C=C2C3=CC=CC=C3NC2=O)C | |
| InChIKey | WUWDLXZGHZSWQZ-UHFFFAOYSA-N |
Semaxanib (SU5416) is a potent and selective VEGFR inhibitor targeting Flk-1/KDR with an IC50 of. It exhibits 20-fold greater selectivity for VEGFR over PDGFRβ, with no activity against EGFR, InsR, or FGFR. By suppressing VEGFR tyrosine kinase activity, semaxanib impairs vascular endothelial cell signaling and blocks angiogenesis and tumor growth. Furthermore, semaxanib combined with chronic hypoxia induces animal models of pulmonary arterial hypertension. [1][2]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
17 mg/mL
(71.34 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 2 mg/mL |
| Water | Insoluble |
| DMSO |
16 mg/mL
(67.14 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
| DMSO |
40 mg/mL
(167.86 mM)
; Warmed with 60°C water bath
; Ultrasonicated
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 4 mg/mL |
| Water | Insoluble |
| DMF | 100 mg/mL |
| DMSO |
20 mg/mL
(83.93 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 4 mg/mL |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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- Semaxanib (SU5416) Mechanism of Action: VEGFR2 Inhibition in Pulmonary Endothelial Cell Research
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- Semaxanib (SU5416) SMILES
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