CAS No. 2260969-36-4
Batch:
Purity:99.00
Chemical Structure
Check the
Selnoflast
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-(1-ethylpiperidin-4-yl)sulfonyl-3-(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)urea | |
|---|---|---|
| CAS Number | 2260969-36-4 | |
| Molecular Formula |
C20H29N3O3S |
|
| Molecular Weight (MW) | 391.53 | |
| InChIKey | OHIFQOUPTWBQLE-UHFFFAOYSA-N |
Selnoflast (RO-7486967) is a selective and reversible small-molecule inhibitor of the NLRP3 inflammasome. By targeting NLRP3, selnoflast blocks assembly of the inflammasome signaling complex, suppressing downstream processing and secretion of pro-inflammatory cytokines such as interleukin-1β (IL-1β) and IL-In ex vivo whole blood assays stimulated with lipopolysaccharide, selnoflast markedly reduces the production of IL-1β, demonstrating potent cellular anti-inflammatory activity. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
78 mg/mL
(199.21 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 13 mg/mL |
| Ethanol | 11 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.