CAS No. 220119-17-5

Batch: Purity:99.96
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Selamectin Chemical Structure
Chemical Structure
Check the Selamectin product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (1R,4S,5'S,6R,6'S,8R,10E,12S,13S,14E,16E,20R,21Z,24S)-6'-cyclohexyl-24-hydroxy-21-hydroxyimino-12-[(2R,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-5',11,13,22-tetramethylspiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-2-one
CAS Number 220119-17-5
Molecular Formula

C43H63NO11
Molecular Weight (MW) 769.96
SMILES CC1CCC2(CC3CC(O2)CC=C(C(C(C=CC=C4COC5C4(C(C=C(C5=NO)C)C(=O)O3)O)C)OC6CC(C(C(O6)C)O)OC)C)OC1C7CCCCC7
InChIKey AFJYYKSVHJGXSN-XHKIUTQPSA-N

Biological Activity

Selamectin is a macrocyclic lactone avermectin that acts as an antiparasitic agent by targeting glutamate-gated chloride channels. By increasing chloride channel conductance and cell membrane permeability to chloride ions, selamectin induces hyperpolarization of invertebrate nerve and muscle cells. This disruption of neurotransmission results in neuromuscular blockade, paralysis, and parasite death, exhibiting potent adulticidal, ovicidal, and larvicidal activity against various invertebrate parasites.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (129.87 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.