CAS No. 2095704-43-9
Batch:
Purity:98.57
Chemical Structure
Check the
SEL201
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 5-(3-amino-1H-indazol-6-yl)-1-[(3-chlorophenyl)methyl]pyridin-2-one | |
|---|---|---|
| CAS Number | 2095704-43-9 | |
| Molecular Formula |
C19H15ClN4O |
|
| Molecular Weight (MW) | 350.80 | |
| SMILES | NC1=N[NH]C2=C1C=CC(=C2)C3=CN(CC4=CC(=CC=C4)Cl)C(=O)C=C3 | |
| InChIKey | YQVUADHJKWJHAF-UHFFFAOYSA-N |
Biological Activity
SEL201 is a potent, ATP-competitive inhibitor of MAP kinase-interacting kinases 1 and 2 (MNK1 and MNK2). By inhibiting MNK kinase activity, it blocks the phosphorylation of eukaryotic initiation factor 4E (eIF4E) at Ser209. This suppression of eIF4E phosphorylation disrupts cap-dependent mRNA translation, leading to reduced expression of oncogenic proteins and inhibition of cancer cell proliferation.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
70 mg/mL
(199.54 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Note: Technical data last updated: Sep 1, 2026.