CAS No. 1933514-13-6
Batch:
Purity:99.01
Chemical Structure
Check the
Sebetralstat
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[(3-fluoro-4-methoxy-2-pyridinyl)methyl]-3-(methoxymethyl)-1-[[4-[(2-oxo-1-pyridinyl)methyl]phenyl]methyl]pyrazole-4-carboxamide | |
|---|---|---|
| CAS Number | 1933514-13-6 | |
| Molecular Formula |
C26H26FN5O4 |
|
| Molecular Weight (MW) | 491.52 | |
| InChIKey | KGMPDQIYDKKXRD-UHFFFAOYSA-N |
Sebetralstat (KVD900) is a potent, selective, competitive, and reversible plasma kallikrein inhibitor. By directly inhibiting plasma kallikrein activity, sebetralstat suppresses activation of the kallikrein-kinin system and blocks the enzymatic cleavage of high-molecular-weight kininogen. This mechanism halts the downstream generation of the proinflammatory peptide bradykinin, thereby preventing excess vascular permeability and suppressing hereditary angioedema phenotypes. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
98 mg/mL
(199.38 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 12 mg/mL |
| Water | Insoluble |
| DMSO |
98 mg/mL
(199.38 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 12 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.