CAS No. 3036109-10-8

Batch: Purity:99.20
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SDU-071 Chemical Structure
Chemical Structure
Check the SDU-071 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-[(4-methoxyanilino)methyl]-N-(4-methoxyphenyl)benzo[h]quinolin-4-amine
CAS Number 3036109-10-8
Molecular Formula

C28H25N3O2
Molecular Weight (MW) 435.52
InChIKey ZWWQETFJXKSVFP-UHFFFAOYSA-N

Biological Activity

SDU-071 acts as a small-molecule inhibitor targeting the BRD4-p53 protein-protein interaction. By interrupting BRD4-mediated transcriptional regulation and downstream chromatin remodeling, SDU-071 suppresses cellular migration, invasion, and cell proliferation in MDA-MB-231 triple-negative breast cancer (TNBC) cells in a concentration-dependent manner. Furthermore, targeted inhibition of BRD4 blocks tumor progression and effectively reduces in vivo tumor growth in preclinical oncological models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 87 mg/mL (199.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Filippakopoulos P, et al. Nature. 2010;468(7327):1067-73.

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Note: Technical data last updated: Sep 1, 2026.