CAS No. 54009-54-0

Batch: Purity:99.51
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SD49-7 Chemical Structure
Chemical Structure
Check the SD49-7 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-hydroxy-N-[(E)-(2-hydroxynaphthalen-1-yl)methylideneamino]benzamide
CAS Number 54009-54-0
Molecular Formula

C18H14N2O3
Molecular Weight (MW) 306.32
InChIKey ZZSJOLDICPVVAV-YBFXNURJSA-N

Biological Activity

SD49-7 is a selective inhibitor of histone lysine-specific demethylase 4 (KDM4) with an ICof. Inhibition of KDM4 by SD49-7 modulates histone H3K9 methylation to suppress MDM2 expression and activate downstream pCIP1 apoptotic signaling. This targeted mechanism impairs self-renewal and cell cycle progression while promoting apoptosis in leukemia stem cells. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 61 mg/mL (199.13 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 5 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Li Y, et al. Theranostics. 2022;12(11):4922-4934.

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Note: Technical data last updated: Sep 1, 2026.