CAS No. 1670-87-7
Batch:
Purity:99.79
Chemical Structure
Check the
SD169
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 1H-indole-5-carboxamide | |
|---|---|---|
| CAS Number | 1670-87-7 | |
| Molecular Formula |
C9H8N2O |
|
| Molecular Weight (MW) | 160.17 | |
| SMILES | C1=CC2=C(C=CN2)C=C1C(=O)N | |
| InChIKey | GQMYQEAXTITUAE-UHFFFAOYSA-N |
Biological Activity
SD169 is a selective inhibitor of p38α MAPK that targets MAP kinase signaling pathways. It attenuates p38 activation and reduces p38 and HSP60 expression in T cells infiltrating pancreatic beta islets. By modulating p38 MAPK pathway activity, SD169 suppresses proinflammatory T-cell responses, mitigating insulitis and preventing the progression of autoimmune diabetes in preclinical animal models. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
32 mg/mL
(199.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 32 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.