CAS No. 2497585-50-7
Batch:
Purity:97.45
Chemical Structure
Check the
SD-436
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | [[2-[[(5S,8S,10aR)-8-[[(2S)-5-amino-1-[[(2S)-3-(3,4-difluorophenyl)-1-[4-[4-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]but-3-ynyl]piperidin-1-yl]-1-oxopropan-2-yl]amino]-1,5-dioxopentan-2-yl]carbamoyl]-3-methoxycarbonyl-6-oxo-1,2,4,5,8,9,10,10a-octahydropyrrolo[1,2-a][1,5]diazocin-5-yl]carbamoyl]-1-benzothiophen-5-yl]-difluoromethyl]phosphonic acid | |
|---|---|---|
| CAS Number | 2497585-50-7 | |
| Molecular Formula |
C58H62F4N9O14PS |
|
| Molecular Weight (MW) | 1248.20 | |
| InChIKey | FLMMCKAIYLDKIN-PBKIRHPCSA-N |
SD-436 is a potent and selective proteolysis targeting chimera (PROTAC) degrader of signal transducer and activator of transcription 3 (STAT3). Targeted degradation of STAT3 disrupts downstream STAT3 signaling pathways, suppressing oncogenic gene expression and cell proliferation. Consequently, targeted STAT3 depletion exerts strong antiproliferative effects and induces marked tumor regression in leukemia and lymphoma xenograft models.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(80.11 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 5 mg/mL |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.