CAS No. 2429877-44-9

Batch: Purity:99.76
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SD-36 Chemical Structure
Chemical Structure
Check the SD-36 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name [[2-[[(5S,8S,10aR)-8-[[(2S)-5-amino-1-(benzhydrylamino)-1,5-dioxopentan-2-yl]carbamoyl]-3-[8-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]oct-7-ynoyl]-6-oxo-1,2,4,5,8,9,10,10a-octahydropyrrolo[1,2-a][1,5]diazocin-5-yl]carbamoyl]-1H-indol-5-yl]-difluoromethyl]phosphonic acid
CAS Number 2429877-44-9
Molecular Formula

C59H62F2N9O12P
Molecular Weight (MW) 1158.15
InChIKey JKCSCHXVWPSGBG-OPKPGBGESA-N

Biological Activity

SD-36 is a proteolysis targeting chimera (PROTAC) degrader of STAT3 (Kd ~ that inhibits STAT3-mediated signaling. By promoting the selective degradation of wild-type and mutated STAT3 proteins, SD-36 suppresses STAT3 transcriptional activity. This degradation disrupts downstream STAT3 pathway activation, leading to potent suppression of tumor cell proliferation and marked anti-tumor activity in preclinical models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (86.34 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Bai L, et al. Cancer Cell. 2019;36(5):498-511.e17.

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Note: Technical data last updated: Sep 1, 2026.