CAS No. 627536-09-8
Batch:
Purity:99.67
Chemical Structure
Check the
SD-208
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-(5-chloro-2-fluorophenyl)-N-pyridin-4-ylpteridin-4-amine | |
|---|---|---|
| CAS Number | 627536-09-8 | |
| Molecular Formula |
C17H10ClFN6 |
|
| Molecular Weight (MW) | 352.75 | |
| SMILES | C1=CC(=C(C=C1Cl)C2=NC3=NC=CN=C3C(=N2)NC4=CC=NC=C4)F | |
| InChIKey | BERLXWPRSBJFHO-UHFFFAOYSA-N |
SD-208 is an orally active, selective transforming growth factor-beta receptor I (TGF-βRI/ALK5) kinase inhibitor. By blocking TGF-βRI kinase activity, SD-208 inhibits canonical TGF-β/Smad signaling, specifically preventing the phosphorylation and nuclear translocation of Smad2 and Smad3. This targeted inhibition suppresses downstream cell migration, invasion, and tumor-mediated immunosuppressive phenotypes in glioma models. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
9 mg/mL
(25.51 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
17 mg/mL
(48.19 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
9 mg/mL
(25.51 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
9 mg/mL
(25.51 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.