CAS No. 529-53-3

Batch: Purity:99.92
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Scutellarein Chemical Structure
Chemical Structure
Check the Scutellarein product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 529-53-3
Molecular Formula

C15H10O6
Molecular Weight (MW) 286.24
SMILES C1=CC(=CC=C1C2=CC(=O)C3=C(O2)C=C(C(=C3O)O)O)O

Ordering Information

Biological Activity

Scutellarein is a naturally occurring flavone compound possessing antioxidant, anti-inflammatory, antiviral, and antitumor activities. It acts as an inhibitor of viral replication machinery, including the SARS coronavirus helicase Nsp13, by blocking ATP hydrolysis and nucleic acid unwinding. In cellular models, scutellarein modulates downstream signaling pathways such as NF-kB and STAT3, resulting in suppressed cell proliferation, enhanced apoptosis, and reduced inflammatory mediator release.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 57 mg/mL (199.13 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.