CAS No. 942183-80-4
Batch:
Purity:99.99
Chemical Structure
Check the
SCH772984
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (3R)-1-[2-oxo-2-[4-(4-pyrimidin-2-ylphenyl)piperazin-1-yl]ethyl]-N-(3-pyridin-4-yl-1H-indazol-5-yl)pyrrolidine-3-carboxamide | |
|---|---|---|
| CAS Number | 942183-80-4 | |
| Molecular Formula |
C33H33N9O2 |
|
| Molecular Weight (MW) | 587.67 | |
| SMILES | C1CN(CC1C(=O)NC2=CC3=C(C=C2)NN=C3C4=CC=NC=C4)CC(=O)N5CCN(CC5)C6=CC=C(C=C6)C7=NC=CC=N7 | |
| InChIKey | HDAJDNHIBCDLQF-RUZDIDTESA-N |
SCH772984 is a highly selective ATP-competitive ERK inhibitor targeting ERK1 and ERK2 (IC50 1 nM). By inhibiting ERK1/2 kinase activity, it effectively blocks the MAPK/ERK signaling cascade and suppresses downstream substrate phosphorylation. This blockade disrupts cell cycle progression, inhibits cell proliferation, and triggers apoptosis, showing robust efficacy across various RAS- and BRAF-mutant cancer cell lines. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
14 mg/mL
(23.82 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
6 mg/mL
(10.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
20 mg/mL
(34.03 mM)
; Warmed with 60°C water bath
; Ultrasonicated
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
12 mg/mL
(20.41 mM)
; Warmed with 60°C water bath
; Ultrasonicated
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
14 mg/mL
(23.82 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- SCH772984 Mechanism of Action: ERK1/2 Inhibition in Tumor Cell Research
- SCH772984 Working Concentration | Cell Culture | Treatment
- SCH772984 Solubility in DMSO
- SCH772984 Stock Solution
- SCH772984 Storage
- SCH772984 Stability
- SCH772984 Combination Database
- SCH772984 Molecular Weight
- SCH772984 SMILES
- SCH772984 Chemical Structure (2D and 3D)
- SCH772984 IC50 for Cell-based and Cell-free Assays
- SCH772984 Sigma (ADV465749270)? Try a better option.
- SCH772984 MedChemExpress (HY-50846)? Try a better option.
- SCH772984 Cayman (19166)? Try a better option.
- SCH772984 Santa Cruz (sc-473205)? Try a better option.
- SCH772984 AbMole (M2084)? Try a better option.
- SCH772984 SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.