CAS No. 1313019-65-6
Batch:
Purity:98.02
Chemical Structure
Check the
SC-1
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[4-(4-cyanophenoxy)phenyl]urea | |
|---|---|---|
| CAS Number | 1313019-65-6 | |
| Molecular Formula |
C21H13ClF3N3O2 |
|
| Molecular Weight (MW) | 431.8 | |
| SMILES | FC(F)(F)C1=CC(=CC=C1Cl)NC(=O)NC2=CC=C(OC3=CC=C(C=C3)C#N)C=C2 | |
| InChIKey | HVPZDXDXIQZKHU-UHFFFAOYSA-N |
SC-1 is a sorafenib analogue that acts as a potent STAT3 phosphorylation inhibitor and SHP-1 agonist. By increasing SHP-1 phosphatase activity, SC-1 enhances STAT3 dephosphorylation and suppresses STAT3-mediated signaling pathways. This inhibition downregulates downstream target genes involved in cell survival and proliferation, thereby inducing apoptosis in cancer cells, including hepatocellular carcinoma models.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
86 mg/mL
(199.16 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 86 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.