CAS No. 2772746-58-2

SBI-810 hydrochloride Chemical Structure
Chemical Structure
Check the SBI-810 hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 2772746-58-2
Molecular Formula

C27H34N4O2.ClH
Molecular Weight (MW) 483.05

Ordering Information

Biological Activity

SBI-810 hydrochloride is a β-arrestin-biased, functionally selective allosteric modulator of neurotensin receptor 1 (NTSR1). In the presence of the endogenous ligand neurotensin, SBI-810 hydrochloride fine-tunes NTSR1-mediated G protein signaling cascades in a G protein-specific manner. Specifically, it fully antagonizes neurotensin-induced Gq activation and partially antagonizes Gi1 activation, while remaining permissive toward NTSR1-mediated activation of GoA and G12 protein pathways. [1]

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Note: Technical data last updated: Sep 1, 2026.