CAS No. 1821280-29-8

Batch: Purity:99.89
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SBI-0640756 Chemical Structure
Chemical Structure
Check the SBI-0640756 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 6-chloro-3-[(E)-3-(5-fluoro-3-pyridinyl)prop-2-enoyl]-4-phenyl-1H-quinolin-2-one
CAS Number 1821280-29-8
Molecular Formula

C23H14ClFN2O2
Molecular Weight (MW) 404.82
SMILES C1=CC=C(C=C1)C2=C(C(=O)NC3=C2C=C(C=C3)Cl)C(=O)C=CC4=CC(=CN=C4)F
InChIKey VVWGPQZBDQVQRC-RMKNXTFCSA-N

Biological Activity

SBI-0640756 is a first-in-class small-molecule inhibitor of translation initiation factor eIF4G1 that disrupts the assembly of the eIF4F complex. By preventing the interaction between eIF4G1 and eIF4E, SBI-0640756 inhibits cap-dependent protein synthesis and suppresses downstream AKT and NF-κB signaling pathways. Consequently, this compound attenuates cell growth, impairs cell survival, and suppresses tumor growth in preclinical melanoma models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 80 mg/mL (197.61 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Feng F, et al. Cancer Res. 2018;78(21):6121-6133.

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Note: Technical data last updated: Sep 1, 2026.