CAS No. 489415-96-5

Batch: Purity:99.79
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SBC-115076 Chemical Structure
Chemical Structure
Check the SBC-115076 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (4E)-4-[hydroxy-(3-methyl-4-phenylmethoxyphenyl)methylidene]-1-(3-morpholin-4-ylpropyl)-5-pyridin-4-ylpyrrolidine-2,3-dione
CAS Number 489415-96-5
Molecular Formula

C31H33N3O5
Molecular Weight (MW) 527.61
SMILES CC1=C(C=CC(=C1)C(=C2C(N(C(=O)C2=O)CCCN3CCOCC3)C4=CC=NC=C4)O)OCC5=CC=CC=C5
InChIKey VVYIXKBHQQSREP-ORIPQNMZSA-N

Ordering Information

Biological Activity

SBC-115076 is a potent extracellular proprotein convertase subtilisin/kexin type 9 (PCSK9) antagonist. By targeting extracellular PCSK9, the compound disrupts the binding interaction between PCSK9 and the low-density lipoprotein receptor (LDLR). This inhibition prevents PCSK9-mediated lysosomal degradation of LDLR, resulting in elevated cell-surface receptor density and increased cellular uptake and clearance of LDL cholesterol. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 33 mg/mL (62.54 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.