CAS No. 1629166-02-4
Batch:
Purity:99.94
Chemical Structure
Check the
SBC-110736
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[4-[4-(4-methylphenyl)-2-phenylpiperazine-1-carbonyl]phenyl]acetamide | |
|---|---|---|
| CAS Number | 1629166-02-4 | |
| Molecular Formula |
C26H27N3O2 |
|
| Molecular Weight (MW) | 413.51 | |
| SMILES | CC1=CC=C(C=C1)N2CCN(C(C2)C3=CC=CC=C3)C(=O)C4=CC=C(C=C4)NC(=O)C | |
| InChIKey | PILMFSWQYWYOJC-UHFFFAOYSA-N |
SBC-110736 is a small-molecule inhibitor of proprotein convertase subtilisin kexin type 9 (PCSK9). By targeting PCSK9, this compound prevents the degradation of low-density lipoprotein receptors (LDLR), resulting in enhanced hepatic receptor availability and accelerated clearance of LDL particles. Consequently, SBC-110736 modulates lipid metabolism pathways and effectively lowers circulating plasma cholesterol levels in animal models. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
83 mg/mL
(200.72 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.