CAS No. 182498-32-4
Batch:
Purity:99.95
Chemical Structure
Check the
SB 225002
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-(2-bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea | |
|---|---|---|
| CAS Number | 182498-32-4 | |
| Molecular Formula |
C13H10BrN3O4 |
|
| Molecular Weight (MW) | 352.14 | |
| SMILES | C1=CC=C(C(=C1)NC(=O)NC2=C(C=C(C=C2)[N+](=O)[O-])O)Br | |
| InChIKey | MQBZVUNNWUIPMK-UHFFFAOYSA-N |
SB 225002 is a potent and selective CXCR2 antagonist that inhibits interleukin-8 (IL-8) binding to CXCR2 with an IC50 of 22 nM, demonstrating >150-fold selectivity over other 7-transmembrane receptors. By blocking CXCR2 signaling pathways, SB 225002 attenuates downstream neutrophil activation and migration. Consequently, this compound suppresses IL-8-induced human neutrophil chemotaxis and cell elongation in inflammatory assay models. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
70 mg/mL
(198.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 14 mg/mL |
| Water | Insoluble |
| DMSO |
70 mg/mL
(198.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 16 mg/mL |
| Water | Insoluble |
| DMSO |
70 mg/mL
(198.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
| DMSO |
70 mg/mL
(198.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 18 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.