CAS No. 607742-69-8
| CAS Number | 607742-69-8 | |
|---|---|---|
| Molecular Formula |
C19H19N3O2S |
|
| Molecular Weight (MW) | 353.44 | |
| SMILES | C1CN(CCN1)C2=CC=CC3=CC(=CN=C32)S(=O)(=O)C4=CC=CC=C4 |
SB742457 is a potent and highly selective 5-HT6 receptor antagonist with a p, exhibiting over 100-fold selectivity over other serotonin receptor subtypes. Antagonism of the Gs protein-coupled 5-HT6 receptor inhibits adenylate cyclase activity and downregulates intracellular cAMP production. This modulation enhances central neurotransmission, promoting acetylcholine and glutamate release in cortical and hippocampal brain regions to facilitate cognitive function. [1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
78 mg/mL
(220.68 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 2 mg/mL |
| Water | Insoluble |
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- Mix rapidly (pipette/vortex) upon addition.
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- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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