SB431542 is a selective TGF-β type I receptor (ALK4/5/7) inhibitor. It affects TGF-β/Smad signaling pathways by blocking Smad2/3 phosphorylation, thereby inhibiting epithelial-mesenchymal transition, tissue fibrosis, and cancer metastasis, while promoting stem cell differentiation.
SB431542 Mechanism of Action: ALK5 Inhibition in Pluripotent Stem Cell Research
SB431542 MOA：Targeting ALK5/TGF-β Pathway for Stem Cell Biology and Regenerative Medicine