CAS No. 288150-92-5
| CAS Number | 288150-92-5 | |
|---|---|---|
| Molecular Formula |
C19H18F2N4O |
|
| Molecular Weight (MW) | 356.37 | |
| SMILES | CC1=CC(=C2C=C(C=C(C2=N1)F)F)NC(=O)NC3=CC=C(C=C3)N(C)C |
SB408124 is a selective, non-peptide antagonist targeting the orexin receptor subtype OX1. By selectively inhibiting OX1 receptor signaling, SB408124 modulates downstream G protein-coupled pathway cascades. This functional inhibition alters orexinergic neuronal signaling and affects central neurobiological processes such as feeding behavior, sleep-wake cycles, and energy homeostasis, serving as an important research tool for investigating orexinergic neurocircuitry. [1][2]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
36 mg/mL
(101.01 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.