CAS No. 261901-57-9
Batch:
Purity:99.62
Chemical Structure
Check the
SB269970 HCl
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3-[(2R)-2-[2-(4-methylpiperidin-1-yl)ethyl]pyrrolidin-1-yl]sulfonylphenol;hydrochloride | |
|---|---|---|
| CAS Number | 261901-57-9 | |
| Molecular Formula |
C18H28N2O3S.HCl |
|
| Molecular Weight (MW) | 388.95 | |
| SMILES | CC1CCN(CC1)CCC2CCCN2S(=O)(=O)C3=CC=CC(=C3)O.Cl | |
| InChIKey | XQCJOYZLWFNDIO-PKLMIRHRSA-N |
SB269970 HCl is a potent and selective 5-HT7 receptor antagonist with a pKi of 8.3 and displays greater than 50-fold selectivity over other receptor subtypes. By blocking 5-HT7 receptor activity, SB269970 inhibits serotonin-stimulated adenylate cyclase activity and cAMP accumulation. This modulation of serotonergic signaling downstream regulates neuronal excitability and attenuates anxiety- and depression-like behaviors in animal models. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
11 mg/mL
(28.28 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.