CAS No. 143797-62-0
Batch:
Purity:99.75
Chemical Structure
Check the
SB-200646A
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 143797-62-0 | |
|---|---|---|
| Molecular Formula |
C15H14N4O.ClH |
|
| Molecular Weight (MW) | 302.76 | |
| SMILES | CN1C=CC2=C1C=CC(=C2)NC(=O)NC3=CN=CC=C3.Cl |
SB-200646A is a selective serotonin receptor antagonist targeting 5-HT2B (p, 5-HT2C (p, and 5-HT2A (p. By blocking 5-HT2B and 5-HT2C receptors, SB-200646A inhibits serotonin-stimulated phosphoinositide hydrolysis and downstream intracellular calcium signaling pathways. This selective receptor inhibition attenuates 5-HT2B/2C-mediated physiological responses and produces anxiolytic-like behavioral phenotypes in preclinical models, demonstrating significant selectivity over 5-HT2A receptors. [1][2]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(330.29 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 3 mg/mL |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.