CAS No. 709031-78-7
Batch:
Purity:99.85
Chemical Structure
Check the
Saxagliptin hydrochloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (1S,3S,5S)-2-[(2S)-2-amino-2-(3-hydroxy-1-adamantyl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile;hydrochloride | |
|---|---|---|
| CAS Number | 709031-78-7 | |
| Molecular Formula |
C18H25N3O2.ClH |
|
| Molecular Weight (MW) | 351.87 | |
| InChIKey | TUAZNHHHYVBVBR-NHKADLRUSA-N |
Saxagliptin hydrochloride is a potent, selective, reversible, competitive, and orally active inhibitor of dipeptidyl peptidase-4 (DPP-4). By inhibiting DPP-4 enzymatic activity, it prevents the cleavage and inactivation of incretin hormones, including glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). This action prolongs active incretin signaling, enhancing glucose-dependent insulin secretion and improving glucose homeostasis in models of type 2 diabetes mellitus. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
70 mg/mL
(198.93 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 70 mg/mL |
| Ethanol | 17 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.