CAS No. 177931-17-8
Batch:
Purity:99.94
Chemical Structure
Check the
Sauchinone
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 177931-17-8 | |
|---|---|---|
| Molecular Formula |
C20H20O6 |
|
| Molecular Weight (MW) | 356.37 | |
| SMILES | CC1CC2C3C(C1C)C4=CC5=C(C=C4OC36C(=CC2=O)OCO6)OCO5 |
Biological Activity
Sauchinone is a bioactive lignan isolated from Saururus chinensis that exhibits hepatoprotective, anti-inflammatory, and antioxidant activities. It activates AMP-activated protein kinase (AMPK), leading to the inhibition of hepatic lipogenesis and attenuation of oxidative stress. Downstream, AMPK activation by sauchinone downregulates lipogenic gene expression, reduces intracellular lipid accumulation, and suppresses NF-kB signaling to protect liver tissue from injury.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
5 mg/mL
(14.03 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Note: Technical data last updated: Sep 1, 2026.