CAS No. 2589531-76-8
Batch:
Purity:99.79
Chemical Structure
Check the
AZD5305 (Saruparib)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5-[4-[(7-ethyl-6-oxo-5H-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl]-N-methylpyridine-2-carboxamide | |
|---|---|---|
| CAS Number | 2589531-76-8 | |
| Molecular Formula |
C22H26N6O2 |
|
| Molecular Weight (MW) | 406.48 | |
| InChIKey | WQAVGRAETZEADU-UHFFFAOYSA-N |
Saruparib (AZD5305) is a highly selective inhibitor and chromatin trapper of PARP1. By selectively binding PARP1, it blocks auto-PARylation and traps PARP1 onto damaged DNA, leading to the accumulation of double-strand DNA breaks during DNA replication. This disruption selectively impairs homologous recombination repair-deficient cancer cell survival, inducing DNA damage signaling and apoptotic cell death in susceptible tumor models. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
16 mg/mL
(39.36 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 10 mg/mL |
| Water | Insoluble |
| DMSO |
20 mg/mL
(49.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 2 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.