CAS No. 138794-73-7

Batch: Purity:99.76
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Sardomozide dihydrochloride Chemical Structure
Chemical Structure
Check the Sardomozide dihydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (1E)-1-(diaminomethylidenehydrazinylidene)-2,3-dihydroindene-4-carboximidamide;dihydrochloride
CAS Number 138794-73-7
Molecular Formula

C11H14N6.2ClH
Molecular Weight (MW) 303.19
InChIKey UHEIPGJSFDAPIC-NENXIMLWSA-N

Biological Activity

Sardomozide dihydrochloride is a potent inhibitor of S-adenosylmethionine decarboxylase (SAMDC) with an IC50 of 5 nM. By targeting SAMDC within the polyamine biosynthesis pathway, it disrupts the conversion of S-adenosylmethionine to decarboxylated S-adenosylmethionine, thereby depleting intracellular spermidine and spermine levels. This polyamine depletion leads to the inhibition of cell proliferation, demonstrating broad-spectrum antiproliferative and antitumor activity across various cancer cell lines. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 60 mg/mL (197.89 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 8 mg/mL
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Regenass U, et al. Cancer Res. 1994;54(12):3210-7.

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Note: Technical data last updated: Sep 1, 2026.