CAS No. 91296-87-6
Batch:
Purity:99.72
Chemical Structure
Check the
Sarafloxacin HCl
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 91296-87-6 | |
|---|---|---|
| Molecular Formula |
C20H17F2N3O3.HCl |
|
| Molecular Weight (MW) | 421.83 | |
| SMILES | C1CN(CCN1)C2=C(C=C3C(=C2)N(C=C(C3=O)C(=O)O)C4=CC=C(C=C4)F)F.Cl |
Biological Activity
Sarafloxacin HCl is a fluoroquinolone antibiotic that acts as a potent inhibitor of bacterial DNA gyrase. By targeting the enzyme-DNA complex, it blocks DNA supercoiling and halts bacterial DNA replication and transcription. This inhibition induces DNA double-strand breaks, leading to the disruption of cellular metabolism and broad-spectrum bactericidal activity against Gram-negative and Gram-positive bacteria. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
4 mg/mL
(9.48 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
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Note: Technical data last updated: Sep 1, 2026.