CAS No. 1333210-07-3

Batch: Purity:99.08
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SAR7334 Chemical Structure
Chemical Structure
Check the SAR7334 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-[[(1R,2R)-2-[(3R)-3-aminopiperidin-1-yl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chlorobenzonitrile
CAS Number 1333210-07-3
Molecular Formula

C21H22ClN3O
Molecular Weight (MW) 367.87
SMILES C1CC(CN(C1)C2CC3=CC=CC=C3C2OC4=C(C=C(C=C4)C#N)Cl)N
InChIKey RLKRLNQEXBPQGQ-OZOXKJRCSA-N

Ordering Information

Biological Activity

SAR7334 is a potent and bioavailable inhibitor targeting transient receptor potential canonical 6 (TRPC6) channels. The compound selectively blocks TRPC6 channel activity to suppress intracellular calcium influx. Inhibition of TRPC6-mediated calcium signaling downregulates downstream calcium-dependent signaling pathways, thereby modulating cellular contraction, proliferation, and functional responses in vascular smooth muscle cells and renal tissues. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
1 mg 5 mg 10 mg
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 74 mg/mL (201.15 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 74 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.