CAS No. 1433953-83-3
| IUPAC Name | 2-amino-1-ethyl-7-[(3R)-3-hydroxy-4-methoxy-3-methylbut-1-ynyl]-N-methyl-4-oxo-1,8-naphthyridine-3-carboxamide | |
|---|---|---|
| CAS Number | 1433953-83-3 | |
| Molecular Formula |
C18H22N4O4 |
|
| Molecular Weight (MW) | 358.39 | |
| SMILES | CCN1C(=C(C(=O)C2=C1N=C(C=C2)C#CC(C)(COC)O)C(=O)NC)N | |
| InChIKey | PFMPOBVAYMTUOX-GOSISDBHSA-N |
SAR131675 is a potent and selective VEGFR3 inhibitor with an IC50 ofand Ki ofin cell-free assays, demonstrating 50-fold and 10-fold selectivity over VEGFR1 and VEGFR2, respectively. By suppressing VEGFR3 autophosphorylation and downstream receptor activation, SAR131675 blocks VEGFR3-mediated signaling pathways. Consequently, this compound inhibits endothelial cell proliferation, lymphangiogenesis, and tumor growth, while reducing tumor-associated macrophage infiltration and lymphatic metastasis in preclinical models. [1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
72 mg/mL
(200.89 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 4 mg/mL |
| Water | Insoluble |
| DMSO |
72 mg/mL
(200.89 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
72 mg/mL
(200.89 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
| DMSO |
72 mg/mL
(200.89 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
72 mg/mL
(200.89 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
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- SAR131675 Mechanism of Action: VEGFR3 Inhibition in Endothelial Cell Research
- SAR131675 Working Concentration | Cell Culture | Treatment
- SAR131675 Solubility in DMSO
- SAR131675 Stock Solution
- SAR131675 Storage
- SAR131675 Stability
- SAR131675 Combination Database
- SAR131675 Molecular Weight
- SAR131675 SMILES
- SAR131675 Chemical Structure (2D and 3D)
- SAR131675 Sigma (AMBH303C58DD)? Try a better option.
- SAR131675 MedChemExpress (HY-15458)? Try a better option.
- SAR131675 Cayman (28385)? Try a better option.
- SAR131675 APExBIO (B2301)? Try a better option.
- SAR131675 SDS｜MSDS