CAS No. 89365-50-4
Batch:
Purity:99.9
Chemical Structure
Check the
Salmeterol
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 89365-50-4 | |
|---|---|---|
| Molecular Formula |
C25H37NO4 |
|
| Molecular Weight (MW) | 415.57 | |
| SMILES | C1=CC=C(C=C1)CCCCOCCCCCCNCC(C2=CC(=C(C=C2)O)CO)O |
Biological Activity
Salmeterol is a potent, long-acting β2-adrenergic receptor (β2AR) agonist that exhibits high selectivity for β2AR over the β1-adrenergic receptor isoform. Engagement of the receptor stimulates Gs protein-coupled adenylate cyclase, leading to elevated intracellular cyclic AMP levels and protein kinase A activation. This downstream signaling cascade promotes airway smooth muscle relaxation and inhibits bronchoconstriction. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
83 mg/mL
(199.72 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 83 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.