CAS No. 2095432-58-7
| IUPAC Name | 3-chloro-N-[4-(methylamino)cyclohexyl]-N-[(3-pyridin-4-ylphenyl)methyl]-1-benzothiophene-2-carboxamide;hydrochloride | |
|---|---|---|
| CAS Number | 2095432-58-7 | |
| Molecular Formula |
C28H29Cl2N3OS |
|
| Molecular Weight (MW) | 526.52 | |
| SMILES | CNC1CCC(CC1)N(CC2=CC(=CC=C2)C3=CC=NC=C3)C(=O)C4=C(C5=CC=CC=C5S4)Cl.Cl | |
| InChIKey | CRWTYWYPPITOOZ-UHFFFAOYSA-N |
SAG (Smoothened Agonist) Hydrochloride is a cell-permeable Smoothened (Smo) agonist that activates Hedgehog signaling with an EC50 ofin Shh-LIGHT2 cells. By directly binding to Smo, SAG promotes receptor accumulation at the primary cilium and triggers downstream transcriptional activity mediated by Gli transcription factors. This activation stimulates Hedgehog pathway-dependent cell proliferation and promotes neuronal differentiation in neural progenitor models. [1]
|
Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
82 mg/mL
(155.73 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 50 mg/mL |
| Ethanol | 27 mg/mL |
| Water | 100 mg/mL |
| DMSO |
28 mg/mL
(53.17 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(189.92 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 100 mg/mL |
| Ethanol | 100 mg/mL |
| DMSO |
100 mg/mL
(189.92 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 100 mg/mL |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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- SAG (Smoothened Agonist) Hydrochloride Stock Solution
- SAG (Smoothened Agonist) Hydrochloride Storage
- SAG (Smoothened Agonist) Hydrochloride Stability
- SAG (Smoothened Agonist) Hydrochloride Molecular Weight
- SAG (Smoothened Agonist) Hydrochloride SMILES
- SAG (Smoothened Agonist) Hydrochloride Chemical Structure (2D and 3D)
- SAG (Smoothened Agonist) Hydrochloride SDS｜MSDS