CAS No. 133865-89-1
Batch:
Purity:99.98
Chemical Structure
Check the
Safinamide
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (2S)-2-[[4-[(3-fluorophenyl)methoxy]phenyl]methylamino]propanamide | |
|---|---|---|
| CAS Number | 133865-89-1 | |
| Molecular Formula |
C17H19FN2O2 |
|
| Molecular Weight (MW) | 302.34 | |
| SMILES | CC(C(=O)N)NCC1=CC=C(C=C1)OCC2=CC(=CC=C2)F | |
| InChIKey | NEMGRZFTLSKBAP-LBPRGKRZSA-N |
Safinamide is an orally active, selective, and reversible monoamine oxidase-B (MAO-B) inhibitor with an IC50 value of 98 nM. By inhibiting MAO-B, safinamide prevents dopamine degradation and elevates extracellular dopamine levels. Furthermore, it blocks voltage-dependent sodium channels and state-dependent calcium channels, which suppresses activity-dependent glutamate release and modulates non-dopaminergic glutamatergic signaling pathways to confer neuroprotective activity.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
60 mg/mL
(198.45 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.