CAS No. 149709-44-4
Batch:
Purity:99.42
Chemical Structure
Check the
Sacubitrilat
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (2R,4S)-4-(3-carboxypropanoylamino)-2-methyl-5-(4-phenylphenyl)pentanoic acid | |
|---|---|---|
| CAS Number | 149709-44-4 | |
| Molecular Formula |
C22H25NO5 |
|
| Molecular Weight (MW) | 383.44 | |
| SMILES | CC(CC(CC1=CC=C(C=C1)C2=CC=CC=C2)NC(=O)CCC(O)=O)C(O)=O | |
| InChIKey | DOBNVUFHFMVMDB-BEFAXECRSA-N |
Sacubitrilat (LBQ-657) is a potent, active inhibitor of neprilysin (NEP). By selectively inhibiting NEP activity, sacubitrilat prevents the enzymatic cleavage and degradation of endogenous vasoactive peptides, including atrial natriuretic peptide and brain natriuretic peptide. This inhibition enhances downstream cyclic guanosine monophosphate (cGMP) signaling, driving beneficial physiological functions such as vasodilation, natriuresis, and diuresis while attenuating vascular resistance and cardiac hypertrophy. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
77 mg/mL
(200.81 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 77 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.