CAS No. 149709-62-6
Batch:
Purity:99.77
Chemical Structure
Check the
Sacubitril
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-[[(2S,4R)-5-ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoic acid | |
|---|---|---|
| CAS Number | 149709-62-6 | |
| Molecular Formula |
C24H29NO5 |
|
| Molecular Weight (MW) | 411.49 | |
| InChIKey | PYNXFZCZUAOOQC-UTKZUKDTSA-N |
Sacubitril is a potent and orally active inhibitor of neprilysin (NEP). By suppressing NEP activity, sacubitril prevents the enzymatic degradation of endogenous natriuretic peptides, including atrial natriuretic peptide and brain natriuretic peptide. This inhibition enhances downstream cyclic guanosine monophosphate (cGMP) signaling, thereby promoting natriuresis, diuresis, and vasodilation while attenuating cardiac hypertrophy and fibrotic remodeling. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
82 mg/mL
(199.27 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 82 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.