CAS No. 165377-44-6

Batch: Purity:99.84
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Cutamesine Dihydrochloride Chemical Structure
Chemical Structure
Check the Cutamesine Dihydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 1-[2-(3,4-dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazine;dihydrochloride
CAS Number 165377-44-6
Molecular Formula

C23H32N2O2.2HCl
Molecular Weight (MW) 441.43
SMILES Cl.Cl.COC1=C(OC)C=C(CCN2CCN(CCCC3=CC=CC=C3)CC2)C=C1
InChIKey XWOXAKBQEMQMFH-UHFFFAOYSA-N

Ordering Information

Biological Activity

Cutamesine dihydrochloride (SA4503) is a potent and selective sigma-1 receptor agonist with an IC50 ofin guinea pig brain membranes. Selective activation of sigma-1 receptors by SA4503 modulates intracellular calcium homeostasis and enhances neurotrophic signaling. These biological processes mediate neuroprotective, anti-amnesic, and antidepressant-like downstream phenotypic effects in central nervous system cellular models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 88 mg/mL
DMSO 22 mg/mL (49.83 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 11 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.