CAS No. 1265789-88-5
Batch:
Purity:98.63
Chemical Structure
Check the
S6K-18
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5-tert-butyl-2-(1H-indazol-5-ylcarbamoylamino)thiophene-3-carboxylic acid | |
|---|---|---|
| CAS Number | 1265789-88-5 | |
| Molecular Formula |
C17H18N4O3S
|
|
| Molecular Weight (MW) | 358.41 | |
| SMILES | CC(C)(C)C1=CC(=C(S1)NC(=O)NC2=CC3=C(C=C2)NN=C3)C(=O)O | |
| InChIKey | BSRFCMMJUFQEOX-UHFFFAOYSA-N |
S6K-18 is a selective inhibitor of ribosomal protein S6 kinase beta-1 (S6K1, p70S6K). As a downstream effector of the mTORC1 signaling pathway, S6K1 regulates key cellular processes including protein synthesis and cell growth. Inhibition of S6K1 suppresses the phosphorylation of ribosomal protein S6 and related target substrates, leading to impaired protein translation, cell growth, and cell proliferation in target model systems. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
72 mg/mL
(200.88 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 2 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.