CAS No. 1448584-12-0

Batch: Purity:99.73
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S55746 Chemical Structure
Chemical Structure
Check the S55746 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-(4-hydroxyphenyl)-3-[6-[(3S)-3-(morpholin-4-ylmethyl)-3,4-dihydro-1H-isoquinoline-2-carbonyl]-1,3-benzodioxol-5-yl]-N-phenyl-5,6,7,8-tetrahydroindolizine-1-carboxamide
CAS Number 1448584-12-0
Molecular Formula

C43H42N4O6
Molecular Weight (MW) 710.82
SMILES C1CCN2C(=C(C=C2C3=CC4=C(C=C3C(=O)N5CC6=CC=CC=C6CC5CN7CCOCC7)OCO4)C(=O)N(C8=CC=CC=C8)C9=CC=C(C=C9)O)C1
InChIKey VYXJULKGMXJVGI-XIFFEERXSA-N

Biological Activity

S55746 is an orally active, selective small-molecule inhibitor of BCL-2 (Ki = with minimal affinity for BCL-XL and no binding to MCL-1 or BFL-1. By disrupting the interaction between BCL-2 and pro-apoptotic proteins, S55746 triggers intrinsic apoptosis via activation of BAX and BAK, downstream cytochrome c release, and caspase cleavage. This mechanistic disruption leads to selective apoptosis in BCL-2-dependent hematological cancer cells and induces tumor regression in preclinical xenograft models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (140.68 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Casara P, et al. Oncotarget. 2018;9(28):20075-20088.

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Note: Technical data last updated: Sep 1, 2026.