CAS No. 1265965-22-7
Batch:
Purity:99.73
Chemical Structure
Check the
S49076
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3-[[(3Z)-3-[[4-(morpholin-4-ylmethyl)-1H-pyrrol-2-yl]methylidene]-2-oxo-1H-indol-5-yl]methyl]-1,3-thiazolidine-2,4-dione | |
|---|---|---|
| CAS Number | 1265965-22-7 | |
| Molecular Formula |
C22H22N4O4S |
|
| Molecular Weight (MW) | 438.50 | |
| SMILES | C1COCCN1CC2=CNC(=C2)C=C3C4=C(C=CC(=C4)CN5C(=O)CSC5=O)NC3=O | |
| InChIKey | AREYWCZYVPSHGS-NVMNQCDNSA-N |
S49076 is a novel, potent multitarget receptor tyrosine kinase inhibitor targeting MET, AXL, MER, and FGFR1/2/3. By inhibiting the autophosphorylation of MET, AXL, and FGFR receptors, it effectively suppresses downstream RAS/MAPK and PI3K/AKT signaling cascades. These pathway blockades significantly impair tumor cell proliferation, migration, and survival, while demonstrating robust antitumor activity in preclinical cancer models.
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
87 mg/mL
(198.4 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.