CAS No. 878141-96-9
Batch:
Purity:99.45
Chemical Structure
Check the
S1RA
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 878141-96-9 | |
|---|---|---|
| Molecular Formula |
C20H23N3O2 |
|
| Molecular Weight (MW) | 337.42 | |
| SMILES | CC1=CC(=NN1C2=CC3=CC=CC=C3C=C2)OCCN4CCOCC4 |
Biological Activity
S1RA is a selective sigma-1 receptor (σ1R) antagonist with a binding affinity of Ki =for the human σ1 receptor. By selectively inhibiting σ1R, S1RA modulates central sensitization and nociceptive signaling pathways. This target inhibition blocks pain processing and reduces mechanical and thermal hypersensitivity in preclinical models of neuropathic and inflammatory pain. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
67 mg/mL
(198.56 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 67 mg/mL |
| Ethanol | 19 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.