CAS No. 38821-49-7
Batch:
Purity:98
Chemical Structure
Check the
S(-)-Carbidopa
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid;hydrate | |
|---|---|---|
| CAS Number | 38821-49-7 | |
| Molecular Formula |
C10H14N2O4.H2O |
|
| Molecular Weight (MW) | 244.24 | |
| SMILES | CC(CC1=CC(=C(C=C1)O)O)(C(=O)O)NN.O | |
| InChIKey | QTAOMKOIBXZKND-PPHPATTJSA-N |
Biological Activity
S(-)-Carbidopa is a potent inhibitor of peripheral aromatic L-amino acid decarboxylase (DOPA decarboxylase). By selectively blocking the peripheral decarboxylation of levodopa (L-DOPA) to dopamine, it prevents premature peripheral metabolism of dopamine precursors. This inhibition increases the systemic availability of levodopa for transport across the blood-brain barrier, thereby facilitating central dopamine synthesis and regulating downstream dopaminergic signaling pathways. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| 5%TFA | 6 mg/mL |
| DMSO |
0.01 mg/mL
(0.04 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.