CAS No. 1900754-56-4

Batch: Purity:99.04
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Zamaporvint (RXC004) Chemical Structure
Chemical Structure
Check the Zamaporvint (RXC004) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-[5-methyl-4-[2-(trifluoromethyl)-4-pyridinyl]imidazol-1-yl]-N-(5-pyrazin-2-yl-2-pyridinyl)acetamide
CAS Number 1900754-56-4
Molecular Formula

C21H16F3N7O
Molecular Weight (MW) 439.39
InChIKey QMLOYDPILBUVBV-UHFFFAOYSA-N

Biological Activity

Zamaporvint (RXC004) is an orally active, selective Porcupine inhibitor that targets membrane-bound O-acyltransferase Porcupine to suppress Wnt ligand palmitoylation and secretion. By disrupting the Wnt signaling pathway, it downregulates target genes such as Axin2 and c-Myc, suppressing cell proliferation in Wnt-dependent colorectal and pancreatic cancer models. Additionally, RXC004 promotes cell differentiation, alters tumor glucose metabolism, and stimulates anti-tumor host immunity. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 88 mg/mL (200.27 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 4 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Phillips C, et al. Cancer Res Commun. 2022;2(9):914-928.

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Note: Technical data last updated: Sep 1, 2026.