CAS No. 1092939-17-7
Batch:
Purity:99.99
Chemical Structure
Check the
Ruxolitinib (INCB18424) Phosphate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile;phosphoric acid | |
|---|---|---|
| CAS Number | 1092939-17-7 | |
| Molecular Formula |
C17H18N6.H3O4P |
|
| Molecular Weight (MW) | 404.36 | |
| SMILES | C1CCC(C1)C(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3.OP(=O)(O)O | |
| InChIKey | JFMWPOCYMYGEDM-XFULWGLBSA-N |
Ruxolitinib Phosphate is a potent, selective kinase inhibitor targeting JAK1 and JAK2 with >130-fold selectivity over JAK3. Inhibition of JAK1 and JAK2 interrupts the downstream JAK/STAT signaling pathway, thereby suppressing tumor cell proliferation, inducing cellular apoptosis, and reducing pro-inflammatory cytokine expression across various neoplastic cell models. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
81 mg/mL
(200.31 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 9 mg/mL |
| Water | Insoluble |
| DMSO |
81 mg/mL
(200.31 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
81 mg/mL
(200.31 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 6 mg/mL |
| Water | Insoluble |
| DMSO |
81 mg/mL
(200.31 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 20 mg/mL |
| Ethanol | 3 mg/mL |
| DMSO |
80 mg/mL
(197.84 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 20 mg/mL |
| Ethanol | 8 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Ruxolitinib (INCB18424) Phosphate Clinical Trials
- Ruxolitinib (INCB18424) Phosphate Solubility in DMSO
- Ruxolitinib (INCB18424) Phosphate Stock Solution
- Ruxolitinib (INCB18424) Phosphate Storage
- Ruxolitinib (INCB18424) Phosphate Stability
- Ruxolitinib (INCB18424) Phosphate Molecular Weight
- Ruxolitinib (INCB18424) Phosphate SMILES
- Ruxolitinib (INCB18424) Phosphate Chemical Structure (2D and 3D)
- Ruxolitinib (INCB18424) Phosphate SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.