CAS No. 7460-43-7
Batch:
Purity:99.86
Chemical Structure
Check the
Rubiadin 1-methyl ether
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3-hydroxy-1-methoxy-2-methylanthracene-9,10-dione | |
|---|---|---|
| CAS Number | 7460-43-7 | |
| Molecular Formula |
C16H12O4 |
|
| Molecular Weight (MW) | 268.26 | |
| InChIKey | NTBUBTCXACOEEC-UHFFFAOYSA-N |
Rubiadin 1-methyl ether is a natural anthraquinone compound isolated from Morinda officinalis that acts as an inhibitor of RANKL-induced signaling pathways. It suppresses osteoclastic differentiation and bone resorption by inhibiting the activation of the NF-κB pathway. Additionally, this compound promotes osteoblast proliferation while suppressing tartrate-resistant acid phosphatase (TRAP) activity during osteoclastogenesis, making it a potential therapeutic agent for bone loss disorders. [1][2]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
27 mg/mL
(100.64 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.