CAS No. 154992-24-2

Batch: Purity:99.99
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RU58841 Chemical Structure
Chemical Structure
Check the RU58841 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile
CAS Number 154992-24-2
Molecular Formula

C17H18F3N3O3
Molecular Weight (MW) 369.34
SMILES CC1(C(=O)N(C(=O)N1CCCCO)C2=CC(=C(C=C2)C#N)C(F)(F)F)C
InChIKey ARBYGDBJECGMGA-UHFFFAOYSA-N

Biological Activity

RU58841 is a non-steroidal anti-androgen that acts as a specific antagonist of the androgen receptor (AR). By selectively binding to the AR, RU58841 blocks endogenous androgen interactions, preventing receptor activation and downstream transcriptional signaling pathways. This inhibition reduces androgen-induced responses, suppressing sebaceous gland development and hair loss in preclinical models of androgenetic alopecia. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 74 mg/mL (200.35 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 74 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Battmann T, et al. J Steroid Biochem Mol Biol. 1994;48(1):55-60.

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Note: Technical data last updated: Sep 1, 2026.