CAS No. 551909-15-0
Batch:
Purity:99.82
Chemical Structure
Check the
RTICBM-189
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 551909-15-0 | |
|---|---|---|
| Molecular Formula |
C15H14Cl2N2O |
|
| Molecular Weight (MW) | 309.19 | |
| SMILES | ClC1=CC=C(NC(=O)NCCC2=CC(=CC=C2)Cl)C=C1 |
RTICBM-189 is a brain-penetrant negative allosteric modulator of the cannabinoid type-1 (CB1) receptor. By modulating CB1 receptor signaling, it regulates intracellular calcium mobilization and cAMP pathway signaling downstream of the receptor. Pharmacological evaluation demonstrates selectivity over more than 50 off-target proteins and high central nervous system exposure, which significantly attenuates the reinstatement of cocaine-seeking behavior in rat models without altering locomotion. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
62 mg/mL
(200.52 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.