CAS No. 1173022-16-6
Batch:
Purity:99.88
Chemical Structure
Check the
RS-102895 Hydrochloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 1173022-16-6 | |
|---|---|---|
| Molecular Formula |
C21H22ClF3N2O2 |
|
| Molecular Weight (MW) | 426.86 | |
| SMILES | Cl.FC(F)(F)C1=CC=C(CCN2CCC3(CC2)OC(=O)NC4=CC=CC=C34)C=C1 |
RS-102895 hydrochloride is a potent antagonist of chemokine (C-C motif) receptor 2 (CCR2) that blocks chemokine ligand 2 (CCL2/MCP-1) binding and CCR2-mediated functional activation. Inhibition of CCR2 receptor downstream signaling disrupts monocyte chemotaxis, inflammatory cell recruitment, and localized chemokine signaling, resulting in attenuated macrophage infiltration and reduced pro-inflammatory phenotypes in experimental models of inflammation. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
85 mg/mL
(199.12 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 85 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
- RS-102895 Hydrochloride Solubility in DMSO
- RS-102895 Hydrochloride Stock Solution
- RS-102895 Hydrochloride Storage
- RS-102895 Hydrochloride Stability
- RS-102895 Hydrochloride Molecular Weight
- RS-102895 Hydrochloride SMILES
- RS-102895 Hydrochloride Chemical Structure (2D and 3D)
- RS-102895 Hydrochloride SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.