CAS No. 2924486-45-1
Batch:
Purity:99.57
Chemical Structure
Check the
RP-102124
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 3-chloro-N-[3-[3-(5-methylfuran-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]phenyl]benzamide | |
|---|---|---|
| CAS Number | 2924486-45-1 | |
| Molecular Formula |
C23H16ClN5O2 |
|
| Molecular Weight (MW) | 429.86 | |
| InChIKey | DDIBTZNIAHHIIP-UHFFFAOYSA-N |
Biological Activity
RP-102124 is a first-in-class allosteric inhibitor targeting multi-Rac GTPases, including the oncogenic variant Rac1b. By disrupting Rac GTPase activation, RP-102124 attenuates downstream signaling pathways controlling actin cytoskeleton dynamics and cellular motility. This inhibition results in suppression of cell migration, reduced cytoskeletal rearrangements, and dose-dependent impairment of tumor growth in xenograft models. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(232.63 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
Jump to
Note: Technical data last updated: Sep 1, 2026.